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Samuel's Grande Manor is conveniently located at 8750 Main St. (NY Route 5) in Williamsville, New York. We are minutes away from Exit 49 on the NY I-90 thruway, 15 minutes from the Buffalo Niagara International Airport, and just under a half hour's drive from downtown Buffalo. Our proximity to the airport means there's a variety of near by lodging options for your guests. Valet parking available, with ample parking on-site for events of any size.